An aprotic solvent with low dielectric constant such as xylene is the suitable solvent for the Kolbe-Schmitt reaction. 具有较低介电常数的非质子惰性溶剂二甲苯是Kolbe-Schmitt反应合适的溶剂。
Molecular simulation was used to investigate the reaction mechanism, also the reaction thermodynamics and kinetics were calculated theoretically, strengthening an in-depth understanding of the Kolbe-Schmitt reaction. Experimental and computational methods were used to explore the hybrid catalytic mechanism of K2CO3. 使用分子模拟的方法对反应机理以及反应热力学和动力学进行了理论计算;对催化机理进行了实验与理论的探索,加深了对Kolbe-Schmitt反应的了解。